PhD Biología molecular
Delegació Mèxic

1988-1992 Doctorate. Weizmann Institute of Science, Rehovot, Israel.
Dissertation: The mRNA Framing Pattern Refined through the Analysis of Nucleotide Distributions and Signal Component Compensations with Dr. Edward N. Trifonov.
1984-1986 M.Sc. in Life Sciences, Weizmann Institute of Science
Thesis: Ribosomal Structure Derived from Sequence Analysis with Dr. Edward N. Trifonov
1979-1984 B.Sc.: Basic Biomedical Research, UNAM, Mexico.
Thesis: Computational Programs Applied to Biological Sequences with Dr. José Negrete Martínez
2014-2015 NGS and Systems biologist for INSP (National Institutes of Health of Mexico) and CONACYT (National Science and Technology Council).

2014-2015 Member of the Board of Directors of The National Science Prevention Coalition (USA) an organization to promote evidence based social and economic policies.

1992-2016 Full time researcher principal investigator at The National University of Mexico.

2010 Mexico City Congress generates bill to promote lab research lines:

2004 Referee for CONACYT scientific projects in Mexico.
2001-2003 Director for PostDoctoral researcher.
1999 Referee for contributions to the 1998 Pacific Symposium on Biocomputing.
1996 Referee for COLCIENCIAS science and technology agency of Colombia.
1996-2002 Member of the Commitee for Supercomputing of the National University of Mexico.
1995-2002 Coordinator of project (Genia) for the design of system that can analyze protein and genetic networks.
1993-1996 Mentor of PhD students, M.Sc and B.Sc. students. Member of PhD Tutorial Comitees.

Patents in process of Registration
Oligonucleotide for HIV RT inhibition
Oligonucleotide for therapeutics in Breast Cancer

Additional information
Recipient of the JFK y Feinberg Foundation Fellowship from the Weizmann Institute of Science, Israel (1987-1992).
Recipient of Fellowship from the USA-Mexico Binational Foundation through the National Academy of Sciences of Mexico for a scientific visit at Rockefeller University in NYC. (July, 1995).
Assignment of Fellowship from the Rotary Club of Morelos (1987).
Assignment of SEP/IPN-CONACyT fellowship (1984).
Included in: NORTH AMERICAN SCIENTISTS, AN INTRODUCTION, Marquis Who’s in Science and Engineering, Marquis’ Who’s Who in the World.

Participation in Meetings
2001, Session Chairman WSEAS, Jaimaica 2000, Satphys2001, International Conference on Complex Systems Boston, Mass. September,. 1997.,1st. UICC (Union Internationale Contre le Cancer) meeting on Cancer management, Vienna, Austria, 1997. International Meeting on Intelligent Systems for Molecular Biology, Halkidiki, Greece, 1997. The Fifth International Nature Genetics conference on Functional Genomics: From Genes to Drugs Washington, D.C. 1997. International Meeting on Bioinformatics, Jerusalem, Israel, November, 1996. International Meeting on Bioinformatics, Baltimore, Md. USA, June, 1996. International Meeting on Bioinformatics, Sn. Francisco, Cal., USA, June, 1995. International Meeting on Oligonucleotide Therapies, Sn Diego, Cal. USA June, 1995. International Congress on Biochemistry and Molecular Biology, New Delhi, India, September,1994. First International Conference on Intelligent Systems for Molecular Biology Washington, D.C., July, 1993. Sante Fe Conference on Computational Biology, Santa Fe, N.M, November,1992. Computational Methods in Genome Research, Heidelberg, Germany, July, 1992.
Member or the National System of Researchers (SNI) of Mexico NECSI

Chapters in Books
1 Compensation effects in the framing code, J. Lagúnez Otero & E. Trifonov, En “Modeling and Computer Methods in Molecular Biology and Genetics”, Ed. V. Ratner, Nova Science Publishers, New York. 1992.

2 Signal Transduction Analysis Using with Boolean ParadigmsM. Armas, O. Armas, M. Cardenas, J. Vasconcelos & J. Lagúnez-Otero in Mathematics and Computers in Modern Science, N. Mastorakis, ed. World Scientific Engineering Society Press, ISBN:960-8052-23, pp 269-174., 2000.

3 Modeling intracellular signaling networks using behaviour-based systems and blackboard architecture, P.P. González, C. Gershenson, M. Cárdenas, J. Lagúnez-Otero , in Mathematics and Computers in Modern Science, N. Mastorakis, ed. World Scientific Engineering Society Press, ISBN:960-8052-23, p 219-22., 2000.
Integration of Computational Techniques for the Modelling of Signal Transduction Pedro Pablo González, Maura Cárdenas, Carlos Gershenson, Jaime Lagúnez-Otero en Advances in Systems Science: Measurement & Control, ISBN:960-8052-39, p 400-410, 2001. mRNA infrastructure complementary to the proofreading site of the ribosome, J. Lagúnez Otero & E. Trifonov, (J. of Biomol. Struct. and Dyn. 10, 455-464 1992).

A plasmidic Citrate Synthase increases symbiotic fitness inRhizobium tropici, M.A. Pardo, J. Lagúnez-Otero & E. Martínez-Romero (J. Mol. Microb., 11,2 315-321, 1993).

Complementarity of mRNA to the 530 loop of SS rRNA – implications for Initiation, J. Lagúnez-Otero (Trends in Biochemical Sciences. 18,11:406-8, 1993 (Factor de impacto 14.3).

The Ribosome as an Exon Detector, Mendoza, L. Lagúnez-Otero, (Biosystems, 38, 45-49, 1996).

Nutritional Value of Edible Insects from Oaxaca, Mexico Julieta Ramos, Pino, M., E., Ladrón de Guevara, O, Lagúnez -Otero, J. (J of Food and Nutrition, 10, 142-157, 1997)

Taxonomy of 5S Ribosomal RNA by the Linguistic Technique: Probing Mitochondrial and Mammalian Sequences, Cardoso Guimarães, R., Trifonov, E. N. & Lagunez-Otero, J. (J. Mol. Evol. 45 (3): 271-277, 1997).

Ab Initio Study of the Acetone Performic Acid Baeyer & Villiger Reaction Mechanism Cardenas, R., Cetina, R., Lagúnez-Otero, J., and Reyes, L. (JPC of the ACS101, 192-200, 1997).

Ab Initio Study of the Reaction Mechanism of Water Dissociation into the Ionic Species OH and H3O+, R. Cárdenas*, J. Lagúnez-Otero and A. Flores**, J., (Journal of Quantum Chemistry, 68, 253-259, 1997).

The Role Played by the 530 Ribosomal Site in Translocation – Interaction with the termination region of mRNA, Mendoza, L., Mondragón, M., and Lagúnez-Otero, J (Biosystems 46, 293-298, 1998).

Semiempirical Studies on the Transition Structure of the Baeyer & Villiger Rarrangement, the reaction of acetone with alkyl and acyl peracids. Renán Cárdenas, Lino Reyes, Jaime Lagúnez-Otero & Raúl Cetina. J. Mol. Structure 497: 211-225, 2000.

Specialized biology from tandem B-turns. Jaime Lagúnez-Otero,1 Andrea Diaz-Villaseñor, 1 and V. Renugopalakrishnan,1, Arch Med Res May-Jun; 33 (3):245-249 2002

The application of abstract topology to RAS-related signal transduction pathways Maura Cárdenas-García a,1, Jaime Lagunez Otero a,2 and Nikolai A. Korneev b,3 In Silico Biology 2, 40, 2002.

Cellulat: an agent based intracellular signalling model, Pedro Pablo González, Maura Cárdenas, David Camacho, Armando Franyuti, Octavio Rosas and Jaime Lagúnez-OteroBiosystems,.68, 171-185, 2003.

Accepted for Publication: An Evolving Neural Network for the Interpretation of Gene _Expression Patterns , Maria del Carmen Marquez, Pedro Pablo Gonzalez, & Jaime Lagunez-Otero.
Use of subgroups for the Analysis of Protein Interations in the Cell, M. Cárdenas-García, N., Kornieev, and J. Lagúnez Otero, A Topology of Protein Interaction Networks, (ISMB 2000, Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology, Altman R. et al. Editores. AAAI Press, p86-92) 2000.

2. Cellulat, Jaime Lagunez-Otero, Pedro Pablo González, Maura Cárdenas, Octavio Roas, & Armando Franyuti, in Artificial Life VIII, Standish, Abass, Bedau (eds) (MIT Press) 2002. pp97-100.
1 Towards Phenotypic Engineering, J. Lagúnez-Otero, M. Strauch, M. Armas Alemán (Abstract) (Folding and Design, Vol. 1, Sup, S4-S5, 1996)

2. The Cell as an Expert System, J. Lagúnez-Otero, Dagstuhl Seminar Report: 215, p.60. ISSN 0940-1121, 1998.


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